Isothiazoline (sometimes called Isothiazolone) is a heterocyclic chemical compound with the chemical formula C3H3NOS, which is a simple compound compared to many heterocycles and has been discovered almost recently.
Reports of this substance were first published in the 1960s. This compound alone has no application; however, its derivatives are widely used as fungicides and disinfectants.
Isothiazoline is usually in light green color and its derivatives are widely used in biological fields as an antimicrobial or antibacterial preservative. This substance easily dissolves in water and has very low toxicity.
Isothiazolines are typically manufactured on an industrial scale by closing a ring of sulfanil propanamide derivatives. These, in turn, are produced from acrylic acid, which is formed through Mercaptopropionic acid. This reaction is called ring-closure. During this reaction, the middle ring of Isothiazoline is also oxidized to form a very valuable substance.
Structure of Isothiazoline

Specifications of Isothiazoline
chemical properties:

Chemical name: Isothiazoline

Molecular formula: C3H3NOS

CAS number: 2-07-1003

Molecular mass / gram per mole: 127/121

Appearance: Liquid

Color: light green

Category: Dangerous substance

Article 1: Analysis of Isothiazoline and other preservatives in gel form
Isothiazoline is a heterocyclic chemical compound related to Isothiazole. Isothiazoline is an antimicrobial preservative that is often used to control fungi, bacteria and algae. Since solutions containing water are the basis for the production of bacteria, Isothiazoline can be easily used in such solutions.
Methy1chloro-Isothiazolinone (MCI) Methyl chloro-Isothiazoline in combination with Methylisothiazoline (MI) is present in Caton (CG) and MCI / MI cosmetics and is a stimulant and sensitizer.
Raw materials for the preparation of Isothiazolines and raw materials include methyl chloride and acrylate.
Some compounds in the isothiazoline family include methyl Isothiazolinone (MI), methyl Chloro Isothiazoline (MCI), benzoIsothiazoline (BIT), and octyl Isothiaroline (OIT).
Article 2: Safety data sheet
According to the instructions for the safety of this product, the use of Isothiazoline products by manufacturers who use it as a sedative and a substance to remove wrinkles is not harmful. However, skin allergies are one of the reported cases of Isothiazoline.
According to reports from the Food and Drug Administration (FDA), methyl Chloroisothiazoline is one of the allergenic chemicals, which in high concentrations can cause chemical burns and the feeling of burning on the skin and membranes.
In some cases, this substance also causes severe skin allergies in contact with the skin, which causes skin damage and burns on the outer surface of the skin, which is in contact with it. The degree of damage and sensitivity depends on the concentration of the solution. Therefore, be more careful when using substances that contain Isothiazoline.
These preservatives are low in molecular weight and can be absorbed by the skin.
Other dangers of using Isothiazoline include adverse effects, such as, poisoning and contamination of water when it is poured.
Sales and application of Isothiazoline
Isothiazolines are antimicrobials used to control bacteria, fungi and algae in cooling water systems, fuel storage tanks, water treatment systems, paper mills and oil extraction systems, wood preservation and anti-pollution agents.
In today's world, there are various products on the market that use Isotiazoline and its derivatives in the production of the products, such as, sunscreens, hand sanitizers, shampoos, cosmetics, lotions, etc.
One of the most important purposes of using Isotiazoline in such products is to inhibit microbial activity, which can potentially damage the product before its expiry date.
Some of these microbial contaminants can cause serious problems for consumer health, designing products that inhibit microbial activity is one of the best ways to maintain consumer safety and health.
Isothiazoline is often purchased by manufacturers of personal care products, such as, shampoos and other hair care products, as well as, special color formulations that often use a combination of MIT and CMIT (known as Kathon CG) or MIT and BIT.
Considering that this product has a very good sales market both in the country and for export, Padidavarandegan Jam Company has tried to be successful in producing this very valuable product in domestic production through maintaining appropriate quality and price.
Some of the uses of Isothiazoline are as the following:
As a preservative in the metalworking and bonding industries
Isocil (R) MW-14 is a high performance bioside for preserving metal fluids, hydraulic fluids, polymer emulsions, pigments.
Suggested applications: Preservative concentrate.
As an industrial water purifier
Isocil (R) RW is a high performance industrial Microbiocyte for use in recirculating water-cooling devices, mold and fungus control, paper mills and air purification systems.
 Suggested applications: Industrial water treatment.
Cosmetics industry
Due to the chemical properties of Isothiazoline, this substance is used as a cosmetic preservative in the health cosmetics industry.
As a disinfectant for medical devices
An Isothiazoline derivative was tested as an antimicrobial to inhibit PCAF activity. In this experiment, Chloroisothiazolinones showed the strongest PCAF inhibitory properties. Therefore, this substance is also used for disinfection of medical devices.


نام شیمیایی ایزوتیازولین
فرمول مولکولی C۳H۳NOS
جرم مولکولی گرم بر مول ۱۲۷/۱۲۱
شکل ظاهری مایع
رنگ سبز روشن
شماره ۲-۰۷-۱۰۰۳ CAS
دسته بندی مواد شیمیایی ماده خطرناک


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